NFL football pool, pick’em, office pool, confidence picks: Select the Chargers in Week 4, 2022

The Tennessee Titans would have been in serious trouble if they had fallen to 0-3 on the season, but they held on for a 24-22 win over Las Vegas last Sunday. Tennessee had a 24-10 lead before needing a stop on a potential game-tying two-point conversion from the Raiders in the final two minutes. The Titans will now go on the road to face Indianapolis during the Week 4 NFL schedule and are three-point underdogs in the latest Week 4 NFL odds at Caesars Sportsbook. Indianapolis was shut out by Jacksonville in Week 2 before knocking off Kansas City in Week 3, making this one of the trickiest Week 4 NFL office pool picks. Where should you slot the Colts in your NFL confidence pool picks? Before you make your Week 4 NFL pick’em predictions, you need to see the Week 4 NFL football pool picks from SportsLine’s proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 4 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Go to SportsLine to see them now.

Top Week 4 NFL office pool predictions

One of the top Week 4 NFL predictions from the model: The Los Angeles Chargers bounce back with a win at Houston on Sunday. Los Angeles is coming off one of the worst performances of any team in the league this season, but the model is not going to overreact to that game. Chargers quarterback Justin Herbert was dealing with a rib injury leading up to the matchup with Jacksonville, so he should be healthier this week.

Los Angeles has taken care of business against Houston in recent meetings, winning five of the last eight games. The Chargers scored 24 points in Week 1 and Week 2 this season, so they should respond with a strong showing on Sunday. Houston’s offense has not scored more than 20 points in any of its first three games, which will make it difficult for the Texans to keep pace. The Chargers win over 60% of the time based on those numbers. See the rest of the model’s Week 4 NFL pool picks here.

How to make Week 4 NFL office pool picks

The model also made the call on every other Week 4 NFL game and has strong picks for potentially close matchups like Cowboys vs. Commanders and Bears vs. Giants. It’s also calling for several big favorites to struggle more than expected and several shocking teams to hang tough. You can only see all of the model’s NFL pool picks here.

So who should you pick in every Week 4 NFL game? And which underdogs should you back? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the top 10 on straight-up picks four of the last six years and went an outstanding 139-103 on top-ranked picks against the spread since 2017.