Cardinals vs. Rams odds, spread, line: Monday Night Football picks, prediction from NFL model on 132-94 run

The Arizona Cardinals are sitting atop the NFC West entering Week 14 and will face a serious test on Monday Night Football. They’ll host the Los Angeles Rams in hopes of extending their lead over the rest of the division. Kyler Murray’s return to action has the Cardinals in position to make a push towards the No. 1 seed in the NFC playoff picture, while the Rams are looking to play themselves back into the NFC West race after losing three of their last four games. 

Kickoff is slated for 8:15 p.m. ET. Arizona is favored by 2.5 points in the latest Cardinals vs. Rams odds from Caesars Sportsbook, while the Over-Under is 51.5. Before locking in your Rams vs. Cardinals picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 14 of the 2021 season on an incredible 132-94 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Rams vs. Cardinals 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Rams vs. Cardinals:

• Cardinals vs. Rams spread: Cardinals -2.5 
• Cardinals vs. Rams over-under: 51.5  
• Cardinals vs. Rams money line: Cardinals -135, Rams +115 
• LAR: Rams are 5-0 against the spread in their last five road games against the Cardinals 
• ARI: Cardinals are 8-2 ATS in their last 10 games

Why the Rams can cover

The Rams struggled in the weeks following Woods’ injury, but finished Week 13 on a high note. Cooper Kupp, Van Jefferson, and Odell Beckham Jr. caught touchdown passes in a blowout victory against the Jacksonville Jaguars. Improved chemistry could help their prolific passing attack keep up with the NFC West leaders.

Los Angeles ranked third in passing yards (3,468) and second in passing touchdowns (30) through Week 13. The Rams’ proficiency through the air has helped them secure a top-five spot in points per game (28). They could go toe to toe with Arizona in a shootout and have had plenty of success against the Cardinals in the past.

Why Cardinals can cover

The Cardinals are among the best in the NFL against the spread this year. They’re 9-3 against the spread overall, and only the Green Bay Packers have covered more. Los Angeles has struggled to cover as consistently and is 2-4 against the spread on the road.

Arizona’s average of 28.6 points per game ranks third in the NFL. The Cardinals haven’t put up elite numbers through the air or on the ground, but their defense has helped them create an abundance of scoring opportunities. Three teams have given up fewer points and four have forced more turnovers. The Rams’ receiving corps could struggle against a secondary that’s allowed the third-fewest receiving yards in 2021.

How to make Rams vs. Cardinals picks 

SportsLine’s model is leaning over on the point total, projecting the teams to combine for 48 points. The model also says one side of the spread has all the value. You can only see the model’s Rams vs. Cardinals picks at SportsLine. 

So who wins Rams vs. Cardinals on Monday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Rams vs. Cardinals spread to jump on, all from the advanced model that is up almost $7,200 on NFL picks, and find out.