Buccaneers vs. Panthers odds, line, spread: 2021 NFL picks, Week 16 predictions from proven computer model

The Tampa Bay Buccaneers and the Carolina Panthers are set to square off in an NFC South matchup at 1 p.m. ET on Sunday at Bank of America Stadium. Carolina is 5-9 overall and 2-5 at home, while the Bucs are 10-4 overall and 4-3 on the road. The Buccaneers had a four-game winning streak snapped last week. The Panthers have lost four consecutive games. 

The Bucs have won the last two meetings between the teams. Tampa Bay is favored by 10 points in the latest Panthers vs. Buccaneers odds from Caesars Sportsbook, and the over-under is set at 43. Before entering any Buccaneers vs. Panthers picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Bucs. You can head to SportsLine to see its picks. Here are several NFL betting lines for Bucs vs. Panthers:

• Panthers vs. Buccaneers spread: Bucs -10
• Panthers vs. Buccaneers over-under: 43 points

What you need to know about the Panthers

Carolina lost to the Buffalo Bills last Sunday, 31-14 on the road. Cam Newton was sacked four times and threw an interception. He was 13 of 39 for 156 yards and an interception and rushed for 71 yards and a TD. Newton will start this week, but Sam Darnold may also see some playing time in his return from a shoulder injury. 

Newton has lost 12 straight starts with the Panthers, dating back to Nov. 2018. D.J. Moore (hamstring) is questionable for Sunday’s game. The Panthers have won 24 of 41 all-time meetings with Buccaneers. 

What you need to know about the Buccaneers

Meanwhile, Tampa Bay was blanked by the New Orleans Saints last Sunday, 9-0. New Orleans beat Tampa Bay for the seventh consecutive time in the regular season and ended Tom Brady’s streak of 255 regular season and playoff games without being shut out. Brady was 26 of 48 for 213 yards and one interception. He also lost a fumble. 

Richard Sherman (Achilles) and Jamel Dean (illness) are questionable for Week 16. Jason Pierre-Paul (shoulder) is doubtful. Mike Evans (hamstring) and Antoine Winfield (foot) are out. Leonard Fournette (hamstring) and Chris Godwin (knee) were placed on injured reserve this week. Antonio Brown is set to return from a three-game suspension.

How to make Buccaneers vs. Panthers picks

The model is leaning over on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Panthers vs. Buccaneers? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.