Yankees vs. Astros odds, prediction, line: 2022 MLB picks, Saturday, June 25 best bets from proven model

American League contenders match up when the New York Yankees (52-19) and the Houston Astros (44-26) play early Saturday afternoon. These teams have split the first two games of the series, with the Astros securing a 3-1 win on Friday night. Gerrit Cole (6-1, 3.14 ERA) will be starting for the Yankees. Cristian Javier (4-3, 3.07 ERA) is on the mound for Houston.

The first pitch is set for 1:05 p.m. ET. New York is the -170 moneyline favorite (risk $170 to win $100) in the latest Astros vs. Yankees odds from Caesars Sportsbook, while Houston is a +150 underdog. The over-under for total runs scored is eight. Before making any Yankees vs. Astros picks, you need to see the MLB predictions and betting advice from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It’s on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Astros vs. Yankees, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Yankees vs. Astros:

• Yankees vs. Astros moneyline: New York -170, Houston +150
• Yankees vs. Astros run-line: New York -1.5 (+125)
• Yankees vs. Astros over-under: 8.5 runs
• Yankees vs. Astros tickets: See tickets at StubHub
• HOU: Astros are 14-3 in their last 17 during Game 3 of a series
• NYY: Yankees are 10-2 in their last 12 vs. American League West

Why you should back the Yankees

Outfielder Giancarlo Stanton is a big-time slugger with a powerful swing for New York. Stanton has the strength and bat speed to drive the ball into any gap. The four-time All-Star can play either outfield position and he owns a rocket of an arm. Stanton is hitting .246 with 16 home runs and 46 RBIs. He’s recorded a home run in back-to-back games.

Second baseman DJ LeMahieu knows how to make consistent contact and has good awareness of the strike zone. LeMahieu displays a good combination of speed and athleticism on the diamond. The three-time All-Star is hitting .260 with six home runs with 29 RBIs. In his last contest, he was 2-for-5 with two singles. 

Why you should back the Astros

Left fielder Yordan Alvarez is off to a hot start for the Astros. Alvarez has fantastic hitting ability for both power and average. The 24-year-old is a reliable run producer and can draw his fair share of walks. Alvarez is 12th in the majors in batting average (.317), tied for second in home runs (22), and fifth in RBIs (55).

Third baseman Alex Bregman has outstanding hands with superb bat speed. Bregman can spray the ball all across the diamond and get on base consistently. The two-time All-Star also is a reliable defender in the corner with quick instincts. He has logged nine home runs with 35 RBIs. He’s currently on a seven-game hitting streak. 

How to make Astros vs. Yankees picks

SportsLine’s model is leaning over on the total, projecting 8.8 combined runs. It also says one side of the money line has all the value. You can only get the model’s MLB picks at SportsLine.

So who wins Yankees vs. Astros? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.