Yankees vs. Guardians odds, line, prediction: 2022 MLB picks, Saturday, April 23 best bets from proven model

Yankee Stadium hosts a matinee matchup on Saturday afternoon in the Bronx. The New York Yankees welcome the Cleveland Guardians to town for the second game of a three-game weekend set. The Yankees won the opener by a 4-1 margin on Friday, improving to 8-6 on the season. The Guardians are 7-6 overall and 4-3 on the road. Cal Quantrill (1-0, 3.72 ERA) is starting for Cleveland, with New York sending Nestor Cortes to the hill.

First pitch is at 1:05 p.m. ET in New York. Caesars Sportsbook lists New York as a -180 favorite (risk $180 to win $100) on the money line, while the over-under, or total number of runs Vegas thinks will be scored, is eight in the latest Yankees vs. Guardians odds. Before making any Guardians vs. Yankees picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every MLB game 10,000 times, is off to a sizzling start to the 2022 season. It’s on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Yankees vs. Guardians, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model’s picks. Here are the MLB odds and trends for Guardians vs. Yankees:

• Yankees vs. Guardians money line: Yankees -180, Guardians +160
• Yankees vs. Guardians over-under: 8 runs
• Yankees vs. Guardians run line: Yankees -1.5 (+115)
• CLE: The Guardians are 4-3 on the road
• NYY: The Yankees are 5-3 at home

Why you should back the Guardians

Cleveland is led by a robust offense, and the Guardians deploy one of the best players in baseball. Standout infielder Jose Ramirez is arguably the leading early candidate for the AL MVP award, leading the league with 20 RBI in less than three weeks of action. Ramirez has four home runs and a .392/.439/.765 slash line, punishing opposing pitchers on a regular basis. As a team, Cleveland leads the AL in myriad categories, including runs scored with 69 in 13 games. The Guardians lead the league in batting average (.279), on-base percentage (.340), and slugging percentage (.441), with a top-three mark in doubles (26). 

Cleveland is also above-average in home runs (12) and strikeout avoidance, and the Guardians deploy an elite bullpen to help in run prevention. The Guardians have a 3.23 ERA with a reliever on the mound, with well over three strikeouts per walk. Cleveland relievers are generating 8.49 strikeouts per nine innings with only 2.55 walks per nine innings in 2022. 

Why you should back the Yankees

The Yankees have plenty of offensive firepower. New York has a strong 9.2 percent walk rate to go along with 13 home runs this season, and the Yankees have powerful bats against a Cleveland starter making his MLB debut. Aaron Judge is a perennial star, posting a .280/.368/.540 slash line with three home runs this season. Anthony Rizzo is enjoying the 2022 season, blasting four home runs with 10 RBI and a .532 slugging percentage. 

The Yankees also have run prevention advantages, including an elite bullpen. New York currently leads the AL in bullpen ERA at 2.08, and Yankees relievers have 10.11 strikeouts per nine innings with a ground ball rate north of 50 percent. Cortes is also performing at a tremendous level, throwing 9.1 scoreless innings to begin the 2022 season. In that span, Cortes has 17 strikeouts and only one walk, scattering six hits in the process. After a 2021 season in which he sported a 2.90 ERA, the Yankees have the pitching advantage on paper.

How to make Guardians vs. Yankees picks

SportsLine’s model is leaning over on the total, projecting 8.5 combined runs, and it also says one side of the money line has all the value. You can only get the model’s pick at SportsLine. 

So who wins Yankees vs. Guardians? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.