2022 NFL divisional round picks, odds, prediction, best bets by top model: This four-way parlay pays out 12-1

A spot in the AFC Championship Game will be on the line when the Kansas City Chiefs and Buffalo Bills collide on Sunday at Arrowhead Stadium. One year ago, the Chiefs knocked off the Bills to earn a spot in Super Bowl LV. This year, Buffalo (12-6) is looking for revenge against Kansas City (13-5), which has won 10 of its last 11 games. Kansas City is a two-point favorite in the latest NFL odds from Caesars Sportsbook.

The game is the last of four in the Divisional Round of the 2022 NFL playoffs. On Saturday, the Titans host the upstart Bengals, and the Packers and 49ers collide in Green Bay. Also on Sunday, Tom Brady and the Buccaneers host the Rams. Before making any NFL playoff picks and NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the 2022 NFL divisional round on an incredible 137-97 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in four confident NFL best bets for the NFL divisional round 2022. If you successfully parlay its picks, you’d be looking at a massive payout of around 12-1. You can only see the model’s NFL playoff picks at SportsLine. 

Top divisional round NFL picks

After simulating every NFL playoff game 10,000 times, the model is high on the 49ers to cover as six-point road underdogs against the Packers. San Francisco (11-7) advanced to the Divisional Round of the NFL playoff bracket with a 23-17 upset of the Cowboys on Super Wild Card Weekend. Green Bay (13-4) had last week off by virtue of earning the No. 1 seed in the NFC.

The 49ers can exploit the Packers’ inability to stop the run. During the regular season, Green Bay gave up 4.7 yards per rush; just two teams, the Chiefs (4.77) and Steelers (4.99), gave up more. That bodes well for a San Francisco team that has averaged 4.55 yards per rush since Dec. 16, which ranks 12th in the league over that time.

How to make NFL divisional round parlays

The model also locked in picks for every other second-round 2022 NFL playoff game, and it’s identified a matchup where the line is way off. You can only see the model’s NFL Wild Card Weekend best bets and parlay at SportsLine. 

What are the model’s top 2022 NFL divisional round picks? And which other NFL picks should you target for a massive 12-1 payout? Visit SportsLine now to see the divisional round NFL best bets from a model on a 137-97 run on its top-rated picks, and find out.