2022 NFL playoff odds, picks, line: Cardinals vs. Rams prediction, Wild Card best bets by expert who’s 37-25

It could be another high-scoring game on Monday Night Football when the Arizona Cardinals visit the Los Angeles Rams for the finale of NFL Super Wild Card Weekend 2022. The NFC West rivals face off in the 2022 NFL playoffs after splitting their regular-season series, with each team winning the road matchup. The teams combined for 110 points over the first two matchups, with Arizona (11-6) crushing L.A. 37-20 at SoFi Stadium in Week 4 and the Rams (12-5) taking a 30-23 win in Glendale. Los Angeles has dominated the Cardinals in recent years, but it had its worst defensive performance of the season in the Week 4 loss.

Kickoff is set for 8:15 p.m. ET at SoFi Stadium. The Rams are favored by 3.5 points in the latest Cardinals vs. Rams odds from Caesars Sportsbook, while the over-under for total points scored is 49.5. Before you consider any Rams vs. Cardinals picks or 2022 NFL Playoff predictions, make sure you check out what SportsLine’s resident Rams expert, R.J. White, has to say.

CBS Sports’ Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It’s no surprise, as White has cashed huge twice in the world’s most prestigious football handicapping competition, the Las Vegas SuperContest. 

In addition, White has gone a stunning 37-25-1 on his last 63 picks involving the Rams. Anyone who has followed him is way up.

Now, White has set his sights on Cardinals vs. Rams and just revealed his expert NFL playoff picks and Wild Card Weekend. predictions. You can head to SportsLine now to see White’s picks. Now, here are several NFL odds for Rams vs. Cardinals: 

• Cardinals vs. Rams spread: Los Angeles -3.5
• Cardinals vs. Rams over-under: 49.5 points  
• Cardinals vs. Rams money line: Los Angeles -180, Arizona +155 
• ARI: Cardinals are 13-3-2 against the spread as road underdogs since 2019 
• LAR: Rams are 11-9-1 ATS as home favorites the past three seasons

Why the Rams can cover

Los Angeles is 8-1-1 against the spread in its 10 meetings with Arizona since coach Sean McVay was hired in 2017. The Rams won by at least 10 points in eight of those. Rams quarterback Matthew Stafford is motivated to get his first playoff victory and faces a Cardinals defense that comes off its worst game of the season. It allowed 431 yards in a 38-30 loss to Seattle, and Stafford (4,886 passing yards, third in NFL) and wide receiver Cooper Kupp (NFL-high 1,947 receiving yards) torched opponents most of the season. The Cardinals started the season 7-0 but closed on a 4-6 run.

The Rams are third in the NFL in sacks with 50, and Aaron Donald (12.5), Leonard Floyd (9.5) and Von Miller (five) will be among the pursuers. The Rams have struggled to run the ball consistently, but Sony Michel (845 yards) could find holes against the NFL’s 20th-best run defense (114.8 yards per game).

Why the Cardinals can cover

Arizona is 8-1 against the spread on the road this season, and its balanced offense has caused teams headaches. The Cardinals hope RBs James Conner (752 yards, 15 TDs) and Chase Edmonds (592 yards, 5.1 per carry) are ready to go as both deal with rib injuries. Edmonds rushed for 120 yards in the Week 4 victory, while quarterback Kyler Murray carried the load with 61 yards in Week 14. Murray had 3,787 passing yards and 423 rushing yards despite missing three games.

The Cardinals went 10-7 against the spread during the regular season, have 27 takeaways, and are plus-12 in turnover differential (fourth in NFL). The defense specializes in forcing fumbles and is tied for the NFL lead with 14 recovered. Chandler Jones has forced six, and Markus Golden has caused four and recovered two. Golden leads the team with 11 sacks, while Jones has 10.5.

How to make NFL Playoffs or Cardinals vs. Rams picks

White has analyzed this matchup from all angles, and he is leaning Under on the point total. He also has discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side of the Cardinals vs. Rams spread to back at SportsLine.

So who wins Rams vs. Cardinals on NFL Wild Card Weekend 2022? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see R.J. White’s Rams vs. Cardinals picks and analysis, all from the NFL expert who’s 37-25 on picks involving Los Angeles, and find out.