Week 5 NFL picks, odds, 2021 best bets from proven model: This five-way football parlay pays out 20-1

Written by on October 7, 2021

The new 17-game NFL schedule means that teams won’t begin their bye weeks until Week 6, so Week 5 brings us another 16-game slate. That means there will be plenty of options for bettors looking to craft NFL parlays with big payouts. Parlaying home underdogs is one of the popular NFL bets, and there are five home teams who are being given points in the Week 5 NFL odds at Caesars Sportsbook. The Bengals are 3-1 and have extra rest after playing last Thursday, but they’re three-point home dogs to the Packers.

The Washington Football Team is a 1.5-point home underdog to the Saints on Sunday. Should you consider backing the Bengals and Washington with your Week 5 NFL best bets, or are there other teams with better matchups you should target in the Week 5 NFL spreads? Before making any Week 5 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 5. If you successfully parlay its picks, you would be looking at a massive payout of 20-1. You can only see the model’s Week 5 NFL picks at SportsLine

Top Week 5 NFL picks

After simulating every NFL game 10,000 times, the model is high on the Cardinals to cover as five-point favorites at home against the 49ers. The Cardinals are getting exactly what they hoped for when they hired Kliff Kingsbury and drafted Kyler Murray: a dynamic offense capable of moving the ball at will and scoring points.

The Cardinals lead the NFL in scoring (35.0 points per game) and total offense (440.5 yards per game) through four games with Murray looking like an MVP candidate. The former Heisman Trophy winner is completing 76.1 percent of his passes for 1,273 yards and nine touchdowns while also adding 109 rushing yards and three more scores on the ground.

Arizona has already blown out a pair of playoff teams from a season ago with a 38-13 win over the Titans and a 37-20 win over the Rams as underdogs last week. Now, they’re taking on a banged-up 49ers squad that could be without Jimmy Garoppolo and Trent Williams on Sunday. That’s a big reason why the model says the Cardinals cover in over 50 percent of simulations.

How to make Week 5 NFL parlays

The model also jumped on four other matchups where it says the line is off, including a divisional battle and a game between two playoff teams from a season ago. You can only see the model’s NFL Week 5 best bets at SportsLine

What are the model’s top Week 5 NFL picks? And which other matchups should you target for a 20-1 payout? Visit SportsLine now to see the Week 5 NFL best bets from a model on a 124-82 run on its top-rated picks, and find out.

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