Week 1 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay returns 25-1

The Kansas City Chiefs will try to continue their Week 1 success under coach Andy Reid when they face the Arizona Cardinals on Sunday. Since Reid took over in 2013, the Chiefs are 8-1 in Week 1, the best record in the NFL over that stretch. The Cardinals are 2-0-1 since Kliff Kingsbury took over as coach in 2019. Kansas City is favored by 4.5 points in the latest NFL odds from Caesars Sportsbook, while the over/under for total points scored is 53.5. The game is one of 16 on a loaded Week 1 NFL schedule. Other key NFL matchups include the reigning Super Bowl champion Rams hosting the Bills in the 2022 NFL Kickoff Game and the Broncos‘ Russell Wilson returning to Seattle to face his former team, the Seahawks. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine. 

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Indianapolis Colts to cover as eight-point road favorites against the Houston Texans. Indianapolis enters the season as the favorite to win the AFC South, at -140 at Caesars Sportsbook. Houston is +4000 to win the division, the longest NFL odds of any team to win any division this season.

Colts running back Jonathan Taylor has an excellent track record against the Texans. In four games against Houston, Taylor is averaging 6.2 yards per rush, his fifth-best average against any team. In addition, he has scored six touchdowns against the Texans, the most he has scored against any team. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine. 

What are the model’s top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and find out.